Mahendranagar, officially known as Bhimdattanagar, is a municipality in Kanchanpur District of Sudurpashchim Province, Nepal. The city and the municipality were named Mahendranagar in honour of the late King Mahendra of Nepal. After becoming a republic in 2008, the Mahendranagar municipality name was changed to Bhimdatta municipality in honour of the revolutionary farmer leader Bhimdatta Panta. It is surrounded by Bedkot Municipality in the east, Dadeldhura District in the north, Shuklaphanta National Park in the south and Uttarakhand, India in the west.
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{"slip": { "id": 177, "advice": "Everyone has their down days. Don't take it out on innocent bystanders."}}
{"type":"standard","title":"3-Keto-5α-abiraterone","displaytitle":"3-Keto-5α-abiraterone","namespace":{"id":0,"text":""},"wikibase_item":"Q30647374","titles":{"canonical":"3-Keto-5α-abiraterone","normalized":"3-Keto-5α-abiraterone","display":"3-Keto-5α-abiraterone"},"pageid":54389883,"thumbnail":{"source":"https://upload.wikimedia.org/wikipedia/commons/thumb/6/63/3-Keto-5%CE%B1-abiraterone.svg/330px-3-Keto-5%CE%B1-abiraterone.svg.png","width":320,"height":284},"originalimage":{"source":"https://upload.wikimedia.org/wikipedia/commons/thumb/6/63/3-Keto-5%CE%B1-abiraterone.svg/1215px-3-Keto-5%CE%B1-abiraterone.svg.png","width":1215,"height":1080},"lang":"en","dir":"ltr","revision":"1184633741","tid":"061e9443-80ba-11ee-91ba-b8d39d7c4bdb","timestamp":"2023-11-11T17:44:55Z","description":"Chemical compound","description_source":"local","content_urls":{"desktop":{"page":"https://en.wikipedia.org/wiki/3-Keto-5%CE%B1-abiraterone","revisions":"https://en.wikipedia.org/wiki/3-Keto-5%CE%B1-abiraterone?action=history","edit":"https://en.wikipedia.org/wiki/3-Keto-5%CE%B1-abiraterone?action=edit","talk":"https://en.wikipedia.org/wiki/Talk:3-Keto-5%CE%B1-abiraterone"},"mobile":{"page":"https://en.m.wikipedia.org/wiki/3-Keto-5%CE%B1-abiraterone","revisions":"https://en.m.wikipedia.org/wiki/Special:History/3-Keto-5%CE%B1-abiraterone","edit":"https://en.m.wikipedia.org/wiki/3-Keto-5%CE%B1-abiraterone?action=edit","talk":"https://en.m.wikipedia.org/wiki/Talk:3-Keto-5%CE%B1-abiraterone"}},"extract":"3-Keto-5α-abiraterone, also known as 17-(3-pyridyl)-5α-androst-16-en-3-one, is an active metabolite of abiraterone acetate that has been found to possess androgenic activity and to stimulate prostate cancer progression. It is formed as follows: abiraterone acetate to abiraterone by esterases; abiraterone to Δ4-abiraterone by 3β-hydroxysteroid dehydrogenase/Δ5-4 isomerase; and Δ4-abiraterone to 3-keto-5α-abiraterone by 5α-reductase. 3-Keto-5α-abiraterone may counteract the clinical effectiveness of abiraterone acetate, and so inhibition of its formation using the 5α-reductase inhibitor dutasteride is being investigated as an adjunct to abiraterone acetate in the treatment of prostate cancer.","extract_html":"
3-Keto-5α-abiraterone, also known as 17-(3-pyridyl)-5α-androst-16-en-3-one, is an active metabolite of abiraterone acetate that has been found to possess androgenic activity and to stimulate prostate cancer progression. It is formed as follows: abiraterone acetate to abiraterone by esterases; abiraterone to Δ4-abiraterone by 3β-hydroxysteroid dehydrogenase/Δ5-4 isomerase; and Δ4-abiraterone to 3-keto-5α-abiraterone by 5α-reductase. 3-Keto-5α-abiraterone may counteract the clinical effectiveness of abiraterone acetate, and so inhibition of its formation using the 5α-reduct